Active Compound in Cannabis Found to Shield the Brain from Alzheimer’s Disease

Bad news for Alzheimer’s disease: THC (the active chemical compound in marijuana) is officially acknowledged to remove the toxic bundle of amyloid beta protein that onsets the evolution of the disease, ultimately damaging the brain beyond repair.

This late discovery is backed up by previous studies revealing the effective and protective qualities of cannabinoids and THC over patients suffering from this neurodegenerative disease.

Little is known about what exactly causes Alzheimer’ disease, but so far it’s believed to be caused by two types of lesions: neurofibrillary tangles and amyloid plaques. The amyloid plaques form dense groups between the neurons, and the neurofibrillary tangles are produced by defective tau proteins that bundle up into a thick, insoluble mass in neurons.

The biological mechanism behind the formation of these lesions is yet a mystery, but recent studies have linked the inflammation in brain tissue to the spread of amyloid plaques and neurofibrillary tangles.

Inflammation within the brain is a major component of the damage associated with Alzheimer’s disease, but it has always been assumed that this response was coming from immune-like cells in the brain, not the nerve cells themselves,” said Antonio Currais, member of Scripps Research Institute.

When we were able to identify the molecular basis of the inflammatory response to amyloid beta, it became clear that THC-like compounds that the nerve cells make themselves may be involved in protecting the cells from dying,” he concluded.

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